Scientists at Oregon Health and Science University have made a development that could lead to a greater understanding of Alzheimer’s disease and vascular dementia.
“We’ve missed a major form of cell death in Alzheimer’s disease and vascular dementia,” senior author of the study Dr. Stephen Back told OHSU in a news release. “We hadn’t been giving much attention to microglia as vulnerable cells, and white matter injury in the brain has received relatively little attention.”
The study, in which researchers studied post-mortem human brain tissue from dementia patients, was published in the peer-reviewed journalMicroglia deteriorates in the Alzheimer’s and vascular dementia patient’s white matter of the brain, scientists found., microglia are native brain cells that normally act to remove cellular waste as part of your body’s immune system.
The chain of events of deteriorating microglia seems to play a role in advancing cognitive decline in Alzheimer’s disease and vascular dementia, according to Back. “If iron toxicity is responsible for cell death and negative impact, myelin repair targeted therapies of this pathway could impact how we treat Alzheimer’s and vascular dementia,” Mercyhealth Memory Clinic medical director Dr. Amarish Davé, who was not involved in the study, told Medical News Today.
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