Researchers at the University of Cologne have found that a protein complex impedes the repair of genomic damage in human cells, mice, and the nematode Caenorhabditis elegans. Furthermore, they were able to successfully obstruct this complex with a pharmaceutical agent for the first time. “When we
Researchers at the University of Cologne have discovered a protein complex, called DREAM, that inhibits DNA repair mechanisms in human, mouse, and nematode cells, thereby contributing to aging and disease. They successfully suppressed the DREAM complex with a pharmaceutical agent, boosting the cells’ resilience to DNA damage, and suggesting potential new treatments for aging and cancer, although further research is needed.
“When we suppress the so-called DREAM complex in body cells, various repair mechanisms kick in, making these cells extremely resilient towards all kinds ofdamage,” said Professor Dr. Björn Schumacher, Director of the Institute for Genome Stability in Aging and Disease at theDNA, which holds our genetic data, needs to be safeguarded carefully. However, it’s under constant threat due to environmental factors or our normal metabolism.
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