STELLAR Trial: positive topline data for sotatercept in PAH
Sotatercept is an investigational, potential first-in-class activin receptor type IIA-Fc fusion protein designed to rebalance pro-proliferative and anti-proliferative signaling associated with pulmonary arterial wall and right ventricular remodeling.
Topline results show that the trial met its primary efficacy outcome measure, demonstrating a statistically significant and clinically meaningful improvement in 6-minute walk distance from baseline at 24 weeks, Merck said.
The overall safety profile of sotatercept in STELLAR was generally consistent with what has been observed in phase 2 testing, the release notes. The company plans to present results from the study at an upcoming scientific meeting.
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