'Paxlovid is not the panacea for which we, the amply vaccinated, had hoped.'
of EHRs of > 13,000 individuals in the US experiencing COVID"rebound" after two of the most popular antivirals concluded that age is not a significant risk factor for post–antiviral therapy–associated COVID rebound. But it doesn't appear that they evaluated the phenomenon sufficiently in older individuals, as opposed to just those with preexisting conditions. Granted, there is typically a high correlation between length of existence and existing or preexisting conditions.
But this study is among the first publicly available regarding COVID rebound after antivirals that also looked at vaccination status of participants. Despite finding that patients experiencing rebound had higher EHR-documented vaccination rate than thoseexperiencing rebound, authors report that the differences did not meet thresholds for statistical significance.
Despite this, they state in their conclusion:"Our study showed that the vaccination rates were higher in patients who developed COVID-19 rebound than in those who did not, suggesting that vaccination wascomparison of Paxlovid with molnupiravir use in Hong Kong, conducted during Omicron, reported a 75%"relative risk reduction" in mortality and a 31% relative risk reduction in hospitalization using NM/R over placebo. If replicable, this suggests a significantly decreased risk reduction associated with use of NM/R for Omicron. Not surprising, given the general reduced level of illness severity being seen with Omicron.
As mentioned, Pfizer indicated that only 1%-2% of patients who took Paxlovid in initial clinical trials tested positive for COVID again soon after finishing their dosage. Pfizer has not released figures from later trials using vaccinated participants.
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