With thousands of pesticides in use, the researchers’ new screening approach could make it easier to determine which ones are linked to the disease. Researchers at the University of California, Los Angeles (UCLA) Health and Harvard University have identified 10 pesticides that significantly damag
A UCLA Health and Harvard study identified 10 pesticides currently in use that significantly harm neurons implicated in Parkinson’s disease. The study used California’s pesticide database to find pesticides toxic to dopaminergic neurons, essential for voluntary movement. The research uncovered 53 pesticides potentially linked to Parkinson’s, with a particular blend used in cotton farming showing increased toxicity.
While environmental factors such as pesticide exposure have long been linked to Parkinson’s, it has been harder to pinpoint which pesticides may raise risk for the neurodegenerative disorder. Just in California, the nation’s largest agricultural producer and exporter, there are nearly 14,000 pesticide products with over 1,000 active ingredients registered for use.
Those results were shared for lab analysis led by Richard Krolewski, MD, PhD, an instructor of neurology at Harvard and neurologist at Brigham and Women’s Hospital. He tested the toxicity for most of those pesticides in dopaminergic neurons that had been derived from Parkinson’s patients through what’s known as induced pluripotent stem cells, which are a type of “blank slate” cell that can be reprogrammed into neurons that closely resemble those lost in Parkinson’s disease.
Researchers also tested the toxicity of multiple pesticides that are commonly applied in cotton fields around the same time, according to California’s pesticide database. Combinations involving trifluralin, one of the most commonly used herbicides in California, produced the most toxicity. Previous research in the Agricultural Health Study, a large research project involving pesticide applicators, had also implicated trifluralin in Parkinson’s.
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