Pandemic stress may disrupt ovaries; blood test may improve immunity assessment

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Pandemic stress may disrupt ovaries; blood test may improve immunity assessment
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The following is a summary of some recent studies on COVID-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review.

Pandemic stresses have been linked with disruptions in ovulation for many women without obvious changes to menstrual cycles, according to a new study.Nearly 66% of 112 women studied during the pandemic had ovulation disturbances, compared to only 10% of 301 women studied 13 years earlier, researchers reported on Sunday at, the annual meeting of the Endocrine Society. Ovulation, or the release of an egg from an ovary, generally occurs about two weeks before the start of the menstrual period.

"By comparing the two studies, and especially their daily diaries, we can infer that the SARS-CoV2 pandemic life disruptions cause silent ovulatory disturbances within mostly regular menstrual cycles," study leader Dr. Jerilynn Prior of the University of British Columbia in Vancouver said in a statement. Over time, persistent ovulatory disturbances can increase women's risks for infertility, bone loss, early heart attacks, and breast and endometrial cancers, the researchers said.

Unlike antibodies, T cells do not prevent infection from occurring, "but they protect from disease," said study co-author Dr. Antonio Bertoletti of Duke-NUS Medical School in Singapore, in an email. They "recognize the infected cells... and destroy them. T cells are also important for the efficient maturation of B cells, also help to produce antibodies," he said.

Antibody levels often wane over time, while T cells remain on the alert. In some people with weakened immune systems, COVID-19 vaccines can induce T cell responses even if they do not induce antibody responses. "Measuring T cell activation is critical to assess the full extent of a person's immunity," said coauthor Ernesto Guccione of The Tisch Cancer Institute at Mount Sinai in a statement.

The new test is presently available only for research purposes but is scalable to use broadly in the population, the researchers reported on Monday inBoth commercially available mRNA vaccines are safe, with low risks of major adverse events, according to a large study that tracked 433,672 U.S. veterans for 38 weeks following vaccination.

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