Over 69% of Americans are either overweight or obese, so new oral weight loss medications have the potential to decrease this statistic.
released Monday, the manufacturer released the results from a 68-week trial with 667 adults who are either obese or overweight with one or more comorbidity. On average, participants lost 15.1% of their body weight after 68 weeks compared to 2.4% of body weight from those on the placebo. The results are similar to those from a WegovyIn that trial, participants saw an average change of body weight of 14.9% compared to a 2.4% change in the placebo group over a span of 68 weeks.
The Rybelsus study, which has not been published in a peer-reviewed journal, acknowledged the side effects were comparable to the semaglutide injections, with mainly mild to moderate gastrointestinal adverse events being the most common side effect. These adverse events mainly occurred when the dosage was increased. Novo Nordisk plans to “file for regulatory approval in the US and the EU” this year with availability depending on manufacturing capacity and how it prioritizes its medications.
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