Thomas Südhof says mistakes in co-authored publications are honest errors that don’t affect studies' conclusions
Journals have corrected five of Thomas Südhof's co-authored papers over the past year and retracted another; several more are under investigation.Several research articles co-authored by Nobel Prize–winning neuroscientist Thomas Südhof are under scrutiny after online commentators raised concerns about data duplication, discrepancies in images, and other issues.
Südhof, who works at Stanford University, denies any wrongdoing and says the errors reflect honest mistakes with only one “tangible accusation of misconduct.” He says his group’s work has come under “relentless scrutiny by people who are dedicated to expos mistakes by prominent scientists on social media and blogs.”
Südhof and his team members have responded by posting original data and high-resolution images, such as blots, and explaining the work. He has also dedicated ato debunking the concerns in detail and listing integrity procedures that the lab adheres to. In a bid to preempt scrutiny, Südhof’s co-authors wrote three recent PubPeer posts pointing out mistakes they have found in their own work.
The vast majority of the PubPeer concerns are “pretty innocuous,” Schrag says, though he says a few seem more serious. “When you thoroughly and transparently report data, its easier for people to spot your errors—we shouldn’t necessarily fault people for that.” An integrity sleuth who goes by the pseudonym Smut Clyde and has not been involved in this case says many of the posts seem hypercritical, even if some raised serious issues that warrant corrections and a retraction.
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