Researchers uncover a previously unknown method of genome protection during replication. The safeguarding of cellular genomes is of utmost importance as any damage can result in cancer or cell death. The genome, consisting of the complete set of DNA, is at its most vulnerable stage during replicati
, indicate that targeting this pathway could enhance the effectiveness of cancer treatments.
You studies how cells protect their genomes while they are being duplicated. Early in his career, he worked on the ATR-Chk1 genome-protection pathway — a pathway that controls the cell-division cycle and prevents stalled replication machinery from failing entirely and causing breaks in the DNA. For the past eight years, he and his team painstakingly have been piecing together another previously unknown genome-protection pathway.
Over the years, You and colleagues have identified eight protein factors involved in this genome-protection pathway. Most of them already have inhibitors under development that could be repurposed for cancer studies.
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