New Weapon Against Brain Cancer: Gene Engineered Cell Therapy’s Two-Pronged Assault on Metastatic Melanomas — Acting as a team, twin ste |
Scientists have devised a promising immunotherapeutic approach for treating melanoma brain metastases, offering the potential to significantly improve the survival rate, according to research published in. This innovative therapy involves the use of a ‘twin stem cell model’ whereby one stem cell releases a cancer-killing virus to reduce tumor growth and a second, gene-edited stem cell, immune to the virus, releases proteins to bolster the immune system’s cancer-fighting capabilities.
Overall survival for patients with melanoma that has spread to the brain is only four to six months. Immunotherapies, which harness the power of the immune system to attack cancer cells, have garnered excitement in recent years for their potential to revolutionize the treatment of metastatic melanomas, but results from early clinical studies indicate that the prognosis for most patients remains poor.
The twin stem cells can be delivered via intrathecal injection, a technique already used in the treatment of other diseases. Unlike other immunotherapies that have emerged in recent years, it does not need to be repeatedly administered. The authors emphasize that this approach can be used in other cancers with brain metastasis, such as lung and breast cancer, and are working to design similar treatments for these cancers.
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