A Mount Sinai stem cell model may be able to shed light on the complex biology behind certain psychiatric disorders. In order to map disease risk variants in human neurons, researchers from the Icahn School of Medicine at Mount Sinai used a unique stem cell model. This work may help shed light on t
The research focuses on mapping cis-regulatory components in human neurons that may be connected to the heredity of psychiatric disorders.
The research focuses on identifying cis-regulatory elements in human neurons that could be related to the heritability of psychiatric disorders. Cis-regulatory elements, which include enhancers and promoters, are non-codingregions that control the expression of genes and are essential parts of the genetic regulatory network.
In recent years, GWAS have identified hundreds of gene regions associated with psychiatric disease, though understanding disease pathophysiology has been elusive. The functional genomics approach Dr. Yang and her team developed uses stem cell models that can help resolve the impact of patient-specific variants across cell types, genetic backgrounds, and environmental conditions.
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