Australian scientists have uncovered a new form of antimicrobial resistance – undetectable using traditional laboratory testing methods – in a discovery set to challenge efforts to tackle one of the world’s greatest health threats. Antimicrobial resistance (AMR) is expected to claim 10 million live
A new mechanism has been discovered that enables bacteria to take up nutrients from their human host and bypass antibiotic treatment. This new form of antimicrobial resistance is undetectable using traditional laboratory testing methods.
Now, scientists have unearthed a critical clue to the way some bacteria are managing to dodge antibiotics – a finding expected to be the tip of the iceberg. The research team was led by Dr. Timothy Barnett, Head of the Strep A Pathogenesis and Diagnostics team at the Wesfarmers Centre of Vaccines and Infectious Diseases, based at Telethon Kids Institute in Perth, Western Australia.
“Bacteria need to make their own folates to grow and, in turn, cause disease. Some antibiotics work by blocking this folate production to stop bacteria growing and treat the infection,” Dr. Barnett explained. “Unfortunately, we suspect this is just the tip of the iceberg – we have identified this mechanism in Group A Strep but it’s likely it will be a broader issue across other bacterial pathogens.”
“In order to preserve the long-term efficacy of antibiotics, we need to further identify and understand new mechanisms of antibiotic resistance, which will aid in the discovery of new antibiotics and allow us to monitor AMR as it arises.”
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