'Game-changer' in detecting CRC, other cancers CRCSM
that together comprise a signature biomarker that can be used to detect and diagnose the presence of colorectal cancer from a liquid biopsy in a younger population.
Andrew T. Chan, MD, MPH, a professor of medicine at Harvard Medical School and vice chair of gastroenterology at Massachusetts General Hospital, who was not involved in the research, told"It would be really value-added to have a blood-based screening test," Chan said, adding that researchers have pursued multiple different avenues in pursuit of one.
Yet current screening strategies are insufficient for detecting enough early-onset cases, the authors assert. The researchers found 28 miRNAs that were significantly unregulated in early-onset colorectal cancer tissue samples compared with cancer-free samples and 11 miRNAs unregulated specifically in only the early-onset colorectal cancer samples. Four of these 11 miRNAs were adequately distinct from one another and were detectable in the plasma samples that the researchers would use to train and validate them as a combination biomarker.
By disease stage, the four-miRNA panel identified both early-stage and late-stage early-onset colorectal cancer in the validation cohort.The researchers also assessed the benefit-harm tradeoff of this liquid biopsy assay compared with other screening modalities, taking into consideration the risk for false-positives and false-negatives.
It's not feasible to recommend colonoscopies in people younger than 45 years because of resource constraints, he said, so"this is a wonderful new development to actually have the possibility of a blood-based screening test for younger individuals, especially given that rising incidence of young-onset colorectal cancer."
Malaysia Latest News, Malaysia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
How Mary Peltola Beat Sarah Palin in Alaska’s Special ElectionThe race was an early test of the state’s new ranked-choice voting system, which promises to reduce political polarization by advancing more moderate candidates.
Read more »
GRAPHIC: ‘Winnie the Pooh’ horror film releases first trailerSomething has went very wrong with our 'tubby little cubby all stuffed with fluff.'
Read more »
Why the NHRA Is Failing to Attract Young Sensations to Pro RanksEven 73-year-old NHRA Funny Car legend John Force sees an issue: 'We need new blood. We need new names.'
Read more »
Why the NHRA Is Failing to Attract Young Sensations to Pro RanksEven 73-year-old NHRA Funny Car legend John Force sees an issue: 'We need new blood. We need new names.'
Read more »
Your Blood Type Affects Your Risk of an Early Stroke, Scientists FindPeople with one of the type A blood groups are more likely to have a stroke before the age of 60 compared with people with other blood types, researchers have found.
Read more »
Watch: 'Winnie the Pooh: Blood and Honey' horror film gets grisly trailerPooh and Piglet are on a murderous rampage in the new “Winnie the Pooh: Blood and Honey” trailer, released Wednesday.
Read more »