New 'atlas' of a monkey brain maps 4.2 million cells

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New 'atlas' of a monkey brain maps 4.2 million cells
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Nicola Williams holds a PhD in the History of Science from the University of Leeds, U.K. and currently works as a science writer across an array of subject areas broadly spanning, but not limited to, biology, physics, medicine and technology.

Scientists have revealed an unprecedented"atlas" of a primate brain that maps the organ in greater resolution than ever before, on the scale of single cells.

"Grasping the intricate structure of brain cells is paramount to comprehending the brain's functioning and potential disorders," said Michel Thiebaut de Schotten, director of research at the French National Centre for Scientific Research and a team leader at the Institute of Neurodegenerative Diseases, a research collaboration between CNRS and the University of Bordeaux. He was not involved in the new study.

What distinguishes the new work is the team's"multi-omics" approach that catalogs cells in multiple ways, including transcriptomics and"epigenomics," which looks at chemical tags that sit on top of the cell's DNA. These tags help control which genes are switched on or off. "To our knowledge, these data represent the largest and most comprehensive multimodal molecular atlas in any nonhuman primate to date," the study authors wrote.

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