A new study with mice reveals potential targets for treating dangerous allergic reactions.
, “are line with what people thought but no one was actually able to demonstrate,” says Sebastien Talbot, a neuroimmunologist at Queen’s University who was not involved in the study. The work, he says, could open up new targets to treat severe allergic reactions in people.
To find out, he and colleagues gave the mice ovalbumin—the main protein found in egg whites and a known trigger of anaphylaxis—and used electrodes and microscopy to record and measure neuron activity. As in humans, the rodents’ body temperature dropped—about 10°C. But the mice’s brains didn’t register this as a sudden freeze; instead, brain areas that typically respond to heat had higher levels of activity.
Immunologists have long thought histamine was the main player in anaphylaxis, Talbot says, so it was surprising to him that chymase—and the nervous system—also seem to play a major role. “It was cool find a new mediator that actually triggered a crosstalk between the neurons and the [immune] cells.”
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