Bacterial Injection System Delivers Proteins in Mice and Human Cells With further development, the programmable system could be used in a range of applications including gene therapy and cancer therapy. Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Re
Purified Photorhabdus virulence cassettes , imaged using TEM. Credit: Joseph Kreitz, Broad Institute of MIT and Harvard, McGovern Institute for Brain Research at MITWith further development, the programmable system could be used in a range of applications including gene therapy and cancer therapy.and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals.
Programmed Photorhabdus virulence cassettes bound to a cancer cell, imaged with transmission electron microscopy. Credit: Joseph Kreitz/Broad Institute, McGovern Institute Zhang is senior author on the study and is also the James and Patricia Poitras Professor of Neuroscience at MIT and an investigator at the Howard Hughes Medical Institute.Symbiotic bacteria use the roughly 100-nanometer-long syringe-like machines to inject proteins into host cells to help adjust the biology of their surroundings and enhance their survival.
The team made eCISs that targeted cancer cells expressing the EGF receptor and showed that they killed almost 100 percent of the cells, but did not affect cells without the receptor. Though efficiency depends in part on the receptor the system is designed to target, Kreitz says that the findings demonstrate the promise of the system with thoughtful engineering.
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