With the ability to map dozens of biomarkers at once, a new method could transform testing for conditions including heart disease and cancer.
or, at most, a couple of biomarkers of the same type.
The new method, developed by scientists at Imperial College London in a research collaboration with Oxford Nanopore Technologies , can analyze dozens of biomarkers of different types at the same time. This would potentially allow clinicians to gather more information about a patient's disease. For example, current tests for heart failure look for a couple of common proteins to tell whether the condition is present. The new method was able to additionally detect 40 different types of miRNA molecules, which have the potential to be used as a new class of biomarkers. It can simultaneously examine proteins,like neurotransmitters, and miRNA from the same clinical sample, providing comprehensive data for a more precise diagnosis.
The results of using the new test in this way with the blood of healthy participants, for a proof-of-concept study, have been published inCo-first author Caroline Koch, from the Department of Chemistry at Imperial, said,"There are many different ways you can arrive at heart failure, but our test will hopefully provide a low-cost and rapid way to find this out and help guide treatment options. This kind of result is possible with less than a milliliter of blood.
Co-first author Ben Reilly-O'Donnell, from the National Heart and Lung Institute at Imperial, added,"The ability to monitor different types of molecules at the same time, in the same sample, offers a distinct advantage over traditional analysis methods."
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