Integrated analyses reveal that multiomics captured the heterogeneity of metabolic states accompanying obesity and changes in metabolic health in response to lifestyle intervention which are not apparent in BMI measurements. nrappapo isbsci
, each biomarker usually reflects a specific aspect of obesity, and relationships between the biomarkers remain to be elucidated. In contrast, the omics-based BMI models automatically incorporated well-known biomarkers and, hence, can be regarded as multidimensional profiles of obesity.
A previous study investigating multiomic changes in response to weight perturbations demonstrated that some weight gain-associated blood signatures were reversed during subsequent weight loss while others persisted. We found that MetBMI was more responsive to the healthy lifestyle intervention than actual BMI or ChemBMI, whereas ProtBMI was more resistant to the same intervention.
Our study had several limitations. The analytes that were retained in the omics-based models do not necessarily have causal relationships with obesity phenotypes. These relationships could be indicative of obesity or affected by other factors that were not included in the models. Our measurements did not cover all biomolecules in blood; in particular, proteomics was based on three targeted Olink panels.
In summary, this study highlights the usefulness of blood multiomic profiling for predictive and preventive medicine. It also outlines an unprecedented multiomic characterization of obesity and will serve as a valuable resource for characterizing metabolic health and identifying actionable targets for health management.The main study cohort was derived from 6,223 individuals who participated in a wellness program offered by a currently closed commercial company between 2015 and 2019.
In the current study, to compare the associations between BMI and host phenotypes across different omics, we limited the original cohort to the participants whose datasets contained all main omic measurements from the same first blood draw; a BMI measurement within ±1.5 months from the first blood draw; and genetic information . We also eliminated outlier participants whose baseline BMI was beyond ±3 s.d.
Malaysia Latest News, Malaysia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology - Nature MedicineThe integration of DNA methylation profiling and targeted sequencing with neuropathology improves the diagnostic accuracy of central nervous system tumors in a population-based cohort of more than 1,200 newly diagnosed pediatric patients.
Read more »
Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective - Nature MedicineNew Review: Nicola Segata, Tim Spector & colleagues explain how meta-omics technologies are revealing the intricate links between cardiometabolic health, diet & the gut microbiome. nsegata timspector MireiaVallesc saraheeberry cibiocm KingsCollegeLon
Read more »
Accurate diagnosis of pediatric brain cancers - Nature MedicineNew technologies are improving diagnostic accuracy of pediatric brain cancers, but more is needed from researchers, governments and regulators. News & Views from Elaine Mardis & Pratiti Bandopadhayay. nationwidekids Bando_Lab DFBC_PedCare harvardmed
Read more »
Patient and public involvement within epidemiological studies of long COVID in the UK - Nature MedicinePatient and public involvement within epidemiological studies of longCOVID in the UK Correspondence from AshRouten kamleshkhunti and colleagues. PPIE uniofleicester unibirmingham ucl
Read more »
Candidates who support psychedelics as medicine get a political action committeePsychedelic Medicine PAC will focus on securing federal funding for more research on how magic mushrooms, ketamine and similar substances can treat various disorders.
Read more »
Psychedelic medicine advocates launch PAC to lobby lawmakersAdvocates for using psychedelic drugs to treat addiction, depression and other problems formed a political action committee on Monday to make their case to Congress.
Read more »