A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings. A study led by Lund University in Sweden now sh
that bolsters its antibiotic resistance, which could pave the way for more effective treatment strategies against resistant bacteria.of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings.
During antibiotic treatment, the normal intestinal flora is disturbed, which provides an opportunity for antibiotic resistant bacterial pathogens that are otherwise suppressed though competition with the “good” gut bacteria. One of the most problematic bacterial species isIt is found in our intestines, is resistant to antibiotic treatments and can cause serious diarrheal infections.
“The risk of infection with C. diff is known to increase after treatment with an antibiotic called clindamycin, but the reason for this was unknown. Our research showed a novel protein conveys resistance to the class of antibiotics to which clindamycin belongs,” says Obana Nozomu, assistant professor at the University of Tsukuba and one of the researchers behind the study.
“This newly discovered protein kicks the antibiotic molecule out of the ribosome. We also saw that it combines with another resistance factor. The second chemically modifies the ribosome so that the antibiotic molecules to bind less tightly to it. The extra-potent resistance is the result of two mechanisms, two factors, which combine and in so doing give the bacteria its ‘superpowers’ against antibiotics,” says Gemma C.
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