Using AI to find molecules from extinct species that could have antimicrobial potential could lead to new drugs to treat human infection. NBThighlight
). This open-source machine learning tool leverages a pan-protease cleavage site classifier to perform computational proteolysis: thedigestion of human proteins into peptide fragments . We experimentally validate panCleave for the prospection of antimicrobial EPs in modern human secreted proteins and in the archaic proteomes of our closest extinct relatives, Neanderthals and Denisovans .
Furthermore, this study introduces previously uncharacterized antimicrobial subsequences encrypted in archaic human proteins.The panCleave Python pipeline is a protein informatics tool that uses ML for computational proteolysis: thefragmentation of human protein sequences into peptides. The development of this predictive tool was motivated by the hypothesis that protease-agnostic cleavage site prediction could facilitate biologically inspired prospection for encrypted host defense peptides.
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