A cohort study found that patients with type 2 diabetes who were taking metformin had a reduced risk of developing osteoarthritis in comparison to those taking a sulfonylurea. OARSI2023
of preclinical and observational human studies finding potentially protective effects of metformin on osteoarthritis.
The researchers included all patients who were at least 40 years old, had type 2 diabetes, were taking metformin, and had been enrolled in the database for at least 1 uninterrupted year. They excluded anyone withor a prior diagnosis of osteoarthritis, inflammatory arthritis, or joint replacement.
"When stratified by prior exposure to metformin within the sulfonylurea group, the observed benefit associated with metformin ... was attenuated in the people treated with a sulfonylurea with prior exposure to metformin, compared with those treated with a sulfonylurea with no prior exposure to metformin," the authors further reported.
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