Nature research paper: Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells
. n = 4 biological replicates. Mean +/- SD.h, Relative mRNA expression in MTOs infected with shControl plasmid compared to uninfected MTOs and MTOs infected with three different shYAP plasmids. Analysed with a mixed effects linear model after normalizing by, Percentage of Emp1-TOMcells in organoids infected with shControl or shYAP plasmids. Two-sided Wilcoxon rank-sum test. n = 3 7 measurements examined over 4 independent experiments.
Extended Data Fig. 10 KRAS mutations and CAFs specify the HRC population responsible for metastatic relapse., Normalized intensity of EpiHR and coreHRC signature expression in CTOs grouped by gain of function mutation in Kras g12d and loss of function mutations in. Box plots have whiskers of maximum and minimum values; boxes represent first, second and third quartiles. n = 6 5 CTOs; 2 technical replicates. P-values for two-sided T-tests.
. Each dot is a mouse; n = 34 29 . P-value for generalized linear model with negative binomial family., Inducible ablation schedule of nude mice implanted with AKTP Emp1-iCT primary tumours. Resection was not possible due to local spreading of tumours to neighbouring tissue., Primary tumour area measured at sacrifice. Each dot is a mouse; n = 4 , 5 mice. P-value for linear model., Liver metastases generated by MTO Emp1-iCT. Each dot is a mouse; n = 4 , 6 mice.
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