Analysis from a cohort in Israel found that a third booster dose of the BNT162b2 mRNA vaccine in mothers before or during pregnancy was associated with greater protection against COVID-19 hospitalisation in their infants compared to two doses. HebrewU
Our study’s strengths include the use of registry data covering the whole Israeli population, with high data completeness. In addition, the high compliance with COVID-19 vaccination campaigns among the pregnant population in Israel provides a large cohort for analysis. Mandatory reporting to the Israeli national registries limited potential selection bias and provided detailed data on clinical and sociodemographic variables.
This study has several limitations. It is a real-world observational study; therefore, participants were not randomly selected for vaccination. Patients who declined a boosting dose may vary in demographic or obstetric characteristics from other eligible individuals. Sociodemographic variables were unavailable for this study; therefore, we could not control for those potential confounders.
In conclusion, in this national cohort study, a third boosting dose of the BNT162b2 mRNA COVID-19 vaccine during pregnancy was associated with a reduced risk, and a shorter duration, of infant hospitalization for COVID-19 during the first 4 months of life compared to mothers who did not receive a booster. Our data provide evidence to support infant protection against serious COVID-19 disease after maternal vaccination with the third dose during pregnancy.
Python version 3.7.3 and lifelines version 0.24.14 were used for multivariate survival analyses. The SPSS statistical package for Windows, version 24 , was used for descriptive and univariate analyses. Two-sidedReporting summary
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