In individuals with long-term cardiac symptoms after an initially mild course of COVID19, MRI & measurement of CardiacInjury biomarkers commonly detected ongoing inflammation but not structural heart disease. v_puntmann GoetheCVI NMEDclinical
The findings of the current study expand on these previous reports by providing a focused assessment of non-hospitalized individuals with no previous comorbidities, thus allowing a more direct insight into post-infection sequelae. This was purposeful to avoid mixing with the effects of severe disease and the pathophysiology accrued during the severe initial infection. Individuals who require hospitalization are also more likely to have pre-existing heart conditions.
The results of our study may shed light on the underlying pathophysiological mechanisms contributing to cardiac symptoms. We employed CMR imaging techniques to detect diffuse inflammatory myocardial involvement by T1 mapping, which is a non-specific measure of abnormal myocardium, and T2 mapping, which mainly relates to myocardial water content. LGE denotes regional myocardial injury due to the accumulation of the gadolinium-based contrast agent.
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