A new study suggests that Clostridioides difficile is responsible for certain colorectal cancers. According to data gathered by scientists at the Bloomberg Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Kimmel Cancer Center, the bacterial species Clostridioides difficile, or C. dif
) or did not successfully colonize the mice , suggesting that other bacteria were responsible for promoting the colorectal cancer cascade.
To determine which bacteria may be causing tumors in the mice, Sears, along with study co-authors Julia Drewes, Ph.D., assistant professor of medicine, Jie Chen, Ph.D., Jada Domingue, Ph.D., of Johns Hopkins, and colleagues performed additional experiments to see if a single bacterial species or a community of bacteria were promoting tumor formation in the mice.that causes diarrhea, was absent in the samples that did not cause tumors, but was present in the samples that caused tumors in mice.
Cells exposed to this bacterium turned on genes that drive cancer and turned off genes that protect against cancer. These cells produced reactive oxygen species, unstable molecules that can damageA toxin produced by this bacterium — known as TcdB — appears to cause most of this activity, the researchers say. When they used genetically engineeredtoxin called TcdA, mice infected with the TcdB-inactivated microbes produced far fewer tumors than those with TcdB-active ones, while TcdA made by C.
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