Researchers have achieved a significant breakthrough in identifying the primary cause and potential treatment for preeclampsia, a severe pregnancy complication. Experts pinpointed a toxic protein named cis P-tau in the blood and placenta of individuals with preeclampsia. The study describes cis P-tau as a pivotal circulating instigator of preeclampsia. An antibody developed in 2012 to target only the toxic protein while leaving its healthy counterpart unscathed is currently undergoing clinical trials in human patients suffering from traumatic brain injury and Alzheimer's Disease. The antibody has shown promising results in animal models and human cell cultures in treating the brain conditions. Upon testing this antibody in mice, the researchers found the all symptoms associated with preeclampsia were corrected.
Researchers from Western and Brown University have made groundbreaking progress towards identifying the root cause and potential therapy for preeclampsia.
"The root cause of preeclampsia has remained unknown, and without a known cause there has been no cure. Preterm delivery is the only life-saving measure," said Lu, professor of biochemistry and oncology at Schulich School of Medicine & Dentistry. Lu is also a Western Research Chair in Biotherapeutics.P-tau as a crucial culprit and biomarker for preeclampsia.
The researchers were curious whether the same antibody could work as a potential treatment for preeclampsia. Upon testing the antibody in mouse models they found astonishing results.P-tau antibody efficiently depleted the toxic protein in the blood and placenta, and corrected all features associated with preeclampsia in mice.
"Preeclampsia presents immediate dangers to both the mother and fetus, but its long-term effects are less understood and still unfolding," said Sharma."Research has suggested a heightened risk of dementia later in life for both mothers who have experienced preeclampsia and their children." However, the causal link between preeclampsia and dementia is not known.
As researchers delve deeper, how our bodies respond to stress is also emerging as a potential factor in the onset of preeclampsia. Interestingly, Pin1 is a key player in cancer signalling networks, turning on numerous cancer-causing proteins and turning off many cancer-suppressing ones. Found in high levels in most human cancers, it's particularly active in cancer stem cells, which are thought to be central to starting and spreading tumors and are hard to target with existing treatments.
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