Chinese researchers used stem cells from macaques to culture embryo-like structures in a lab.
Using stem cells from a monkey embryo, a team of researchers from the Chinese Academy of Sciences successfully cultured embryo-like structures in lab conditions, but they didn’t just stop there.in the uteruses of living female monkeys to check if they could give rise to fetuses.It is important to understand that human embryonic research is a controversial subject because of the various ethical concerns.
“Because monkeys are closely related to humans evolutionarily, we hope the study of these models will deepen our understanding of human embryonic development, including shedding light on some of the causes of early miscarriages,” said Zhen Liu, one of the study authors, in aThe progression of cultured embryo cells in a female monkey.The Chinese researchers began their experiment with the embryonic stem cells of a macaque.
They were able to successfully implant the embryonic structures into the uteruses of three female monkeys. “Monkey blastoids were very likely to develop gastrulation with major germ-layer formation and lead to early pregnancy under in vitro prolonged culture,” the researchersThe goal of this experiment was to check if their lab-grown embryos could trigger the same hormonal activities as found during normal pregnancy.
They further added, “The suspected gestation sacs and yolk sac disappeared without any further development.” The study authors are now trying to create a betterFurther application of monkey blastoids can help to dissect the molecular mechanisms of primate embryonic development,” said Fan Zhou, one of the corresponding authors.
The CAS team believes that since their in-vitro embryos don’t have the ability to develop into living organisms, they are different from natural embryos and therefore, can be considered for studying early embryonic development in detail.Human stem cell-derived blastoids display similar morphology and cell lineages to normal blastocysts. However, the ability to investigate their developmental potential is limited.
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