Huge US study starts sharing gene findings with volunteers

More than 155,000 Americans who shared their DNA for science are about to learn something in return: Do they have some particularly worrisome genes?

Traditionally such studies are a one-way street -- scientists learn a lot from volunteers who get little personal information in return. But in an unusual move, All of Us participants get to decide if they want to learn health-related genetic findings, long before the study’s finished.

An All of Us genetic counselor broke the news to the Philadelphia woman that she was at increased risk of breast and ovarian cancer because of a gene named BRCA-2. The knowledge “allows you to take charge,” said Peterson, who plans to discuss options with her own doctor such as increased breast cancer screening or whether to consider precautionary ovary removal.Denny estimated 2% to 3% of study participants will learn they have a well-known genetic variant that can cause certain cancers, heart conditions or other disorders. Many more will have genetic variants that affect how their body processes certain medicines.

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