🆕 results in the treatment of advanced ovariancancer have been welcomed by an expert not involved in the trial, even though the study showed an improvement in PFS, and not yet overall survival. ASCO23 OncTwitter
, have shown that maintenance therapy with olaparib and bevacizumab improves outcomes in the first-line treatment of advanced ovarian cancer.mutation," Aghajanian said.
After an initial cycle of paclitaxel/carboplatin chemotherapy, the patients were randomly assigned to one of three regimens: Chemotherapy plus bevacizumab and durvalumab, followed by maintenance therapy with bevacizumab, durvalumab, and olaparib Among HRD-positive patients, those in arm 3 had a significantly longer PFS than those in arm 1, at a median of 37.3 months vs 23 months, or a hazard ratio of 0.49 .
She added that a"PFS effect was observed across all subgroups for the arm 3 vs arm 1 comparison," including in the HRD negative subgroup, at a median of 20.9 months vs 17.4 months, or a hazard ratio of 0.68. The study was sponsored by AstraZeneca, and conducted in collaboration with the European Network of Gynaecological Oncological Trial Groups , GOG Foundation, Inc., and Myriad Genetic Laboratories, Inc.
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