Heat Stroke: Practice Essentials, Pathophysiology, Etiology

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Heat Stroke: Practice Essentials, Pathophysiology, Etiology
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With extreme heat overtaking much of the US, it’s a good time to review the practice essentials of heat stroke.

, sympathomimetic drugs, and many other conditions can increase heat production, thereby increasing body temperature.

Under normal physiologic conditions, heat gain is counteracted by a commensurate heat loss. This is orchestrated by the hypothalamus, which functions as a thermostat, guiding the body through mechanisms of heat production or heat dissipation, thereby maintaining the body temperature at a constant physiologic range.

The efficacy of evaporation as a mechanism of heat loss depends on the condition of the skin and sweat glands, the function of the lung, ambient temperature, humidity, air movement, and whether or not the person is acclimated to the high temperatures. For example, evaporation does not occur when the ambient humidity exceeds 75% and is less effective in individuals who are not acclimated.

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