Researchers have developed a strategy to identify new antimicrobial drugs with therapeutic promise from bacterial datasets, providing clues for discovering alternatives to traditional antibiotics.
, represents a valuable new strategy for identifying novel lysins with antimicrobial activity, according to the editors. They describe the strength of evidence as solid for the therapeutic potential of two such lysins discovered during the study -- PHAb10 and PHAb11. They add that the findings will be of general interest to microbiologists to explore in more detail.
Recent studies on lysins have linked their antimicrobial activity to their internal peptides -- short chains of up to 50 amino acids with antimicrobial peptide-like architecture. This led Zhang and colleagues to see if they could identify new lysins with antimicrobial activity by scanning datasets of bacterial proteomes -- that is, the entire set of proteins expressed by the genome in bacteria -- rather than the genomes themselves.
The team also discovered that both PHAb10 and PHAb11 retained significant antibacterial activity after heat treatment at 100? for one hour, unlike PHAb7, PHAb8 and PHAb9, which lost their effect under these conditions. To understand the thermostability of PHAb10, the team used X-ray crystallography to glean an insight into its crystal structure.
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