Haplotype-aware analysis of somatic copy number variations from single -cell transcriptomes
Extended Data Fig. 3 WGS validation of Numbat CNV calls from scRNA-seq data.
For each sample, the DNA profile is juxtaposed with the copy number profile inferred by the Numbat joint HMM . Gray vertical bars represent centromeres and gap regions. logR, log coverage ratio. BAF, B-allele frequency. logFC, log expression fold-change. pHF, paternal haplotype frequency. BAMP, balanced amplification.
Each dot represents a distinct sample . Center line, mean. ATC5 was excluded from the benchmark due to lack of clear expression of tumor markerThe aneuploidy probability is shown as a color gradient . For each sample , the series of figures respectively show the aneuploidy probabilities by expression evidence, those by allele evidence, those by combined evidence, CopyKAT prediction , and marker gene expression in a t-SNE embedding of gene expression profiles.
Malaysia Latest News, Malaysia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Did you win Saturday’s $270M Powerball drawing? Winning numbers, live resultsThe winning Powerball lottery numbers are drawn Saturday, Sept. 24, 2022, at 10:59 p.m. The Powerball jackpot drawing today (9/24/2022) is worth an estimated $270 million for a single winner.
Read more »
How Do Electric Vehicle Tax Credits Work?A number of EVs are eligible for the federal government's tax credit program, which can reduce what you owe the IRS by up to $7500 for a single tax year.
Read more »
Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit - Nature BiotechnologyReal-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit
Read more »
A competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites - Nature BiotechnologyA competitive precision CRISPR method to identify the fitness effects of transcription factor binding sites
Read more »
Rep. Jamie Raskin: Jan. 6 committee 'aware of' call from White House to rioterRaskin said it's up to the Jan. 6 committee to 'put everything into a comprehensive portrait and narrative timeline of what took place.'
Read more »