Re-engineered bacteria able to target drug-resistant infections in mice, research finds
Genetically modified bacteria could be used to treat intractable lung infections, according to research aiming to combat the threat ofThe research, in mice, showed that a re-engineered bacteria could be used to target drug-resistant infections and make them susceptible to antibiotics that would otherwise be ineffective.
Dr Maria Lluch, of the International University of Catalonia and senior author, described the treatment as a “battering ram that lays siege to antibiotic-resistant bacteria”.“The treatment punches holes in their cell walls, providing crucial entry points for antibiotics to invade and clear infections at their source,” said Lluch. “We believe this is a promising new strategy to address the leading cause of mortality in hospitals.
The bacteria-based treatment doubled mouse survival rate compared with not using any treatment, according to the research carried out at the Centre for Genomic Regulation in Barcelona. Administering a single, high dose of the treatment showed no signs of toxicity in the lungs. Once the treatment had finished its course, the immune system cleared the modified bacteria in a period of four days.
Antimicrobial resistant infections pose a growing threat, directly accounting for at least 1.27 million deaths each year,
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