Global detection of human variants and isoforms by deep proteome sequencing
Owing to its scope, depth and coverage, the dataset reported in this study represents a resource to drive future work on the human proteome. To make this peptide catalog accessible, we have created an online resource—deep-sequencing.app. This resource has a gene-centric design, such that one can query any gene and examine the corresponding peptides, SAPs and splicing junctions detected.
cells were grown at 37 °C with 5% COin Endothelial Growth Media supplemented with EGM Complete Media and antibiotics. HepG2 cells were grown at 37 °C with 5% COin IMDM supplemented with 10% FBS and antibiotics. GM12878 cells were supplemented with 15% FBS and RPMI-1640 medium . hESC-1 cells were prepared according to previously published protocolsfor 5 min at 4 °C. The supernatant was removed, and cells were washed with PBS and centrifuged at 300for 5 min at 4 °C.
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