Inspired by the water-wicking skin of the Australian thorny devil lizard, FLASH capsules can connect directly to stomach tissue to modulate hunger-triggering hormones. A team of researchers at NYU Abu Dhabi (NYUAD), led by Professor Khalil Ramadi, Director of the Laboratory for Advanced Neuroengi
Researchers at NYU Abu Dhabi have developed an ingestible electroceutical device, called the FLASH system, that modulates the gut-brain axis, affecting hunger levels and potentially treating a range of disorders. Inspired by the Australian thorny devil lizard’s skin, the device uses a fluid-wicking capsule to deliver electrical stimulation to stomach tissue, influencing the hunger-stimulating hormone ghrelin.
A team of researchers at NYU Abu Dhabi , led by Professor Khalil Ramadi, Director of the Laboratory for Advanced Neuroengineering and Translational Medicine, have developed a first-of-its-kind ingestible electroceutical device for the neuromodulation of the gut-brain axis, the signaling pathway between the gastrointestinal tract and central nervous system.
Gastric electrical stimulation directly induces the release of the hormone ghrelin, which stimulates hunger, from the gastric mucosa through endoscopic stimulation. Oral ingestion of the FLASH capsule was shown to modulate levels of the ghrelin hormone significantly and repeatedly. In the paper titled
published on April 26, the researchers report the process of developing the FLASH capsules, which are swallowed, deliver stimulation to the stomach, and then excreted safely. The capsules are powered by ingestible batteries, which were shown to deliver stimulation for 20 minutes, and then be excreted within two weeks of ingestion in large animals.
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