Impact of substances on zebrafish embryos shows how the prenatal development of human facial features might also be affected. Some substances in medicines, household items, and the environment are known to affect prenatal child development. In a study published in Toxicological Sciences, resea
This zebrafish larva has been genetically modified so that the bone-forming cells in the face emit a green fluorescence. Normally, they are colorless and transparent, thus almost invisible at this stage. As embryos, their head and tail start to form after just 16 hours. As adults, they grow to be just 2-5 centimeters long. Credit: 2023 Liu et al.
Some substances in medicines, household items, and the environment are known to affect prenatal child development., researchers tested the effects of five drugs on the growth of zebrafish embryos. They found that all five had the same effect, impairing the migration of bone-forming cells which resulted in the onset of facial malformation.
These fluorescent images of live zebrafish embryos show the movement, assembly, and growth of cartilage-forming cells at 48, 72, and 96 hours post-fertilization. Credit: 2023 Liu et al.Whether from birth or through events that happen in life, many people have differences in their facial appearance.
“Bone- and cartilage-forming cells in the head, called cranial neural crest cells , generally move a long distance from where they are first formed around the back of the neck, to their intended destinations such as the jaw or nose,” explained Kawanishi. “We were surprised that regardless of how each chemical acts on cells molecularly, impaired migration of bone-forming cells in early development was responsible for the onset of facial malformation for all the five chemicals.
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