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It's not a cure, but it may offer some relief and constitute an effective part of a treatment regime for glioblastoma patients. Human clinical trials are the next step; patients are cautioned against self-medicating at this stage.of the University Hospital Zurich in Switzerland."As the drug has already been approved, it doesn't have to undergo a complex approval procedure and could soon supplement the standard therapy for this deadly brain tumor.
In all, they tested 132 drugs on tissue cultivated from 27 glioblastoma patients, cataloging more than 2,500 drug responses. And they found, surprisingly, that some antidepressant drugs were effective at suppressing the development of the, a series of reactions in a cell initiated by a stimulus. These cascades suppress cell division, which is the way cancers grow and spread.
The next step was to test the drugs in a living, breathing system: mice with glioblastoma. Mice were transplanted with glioblastoma tumors, and then assigned a group. The control group was left untreated, while a second group of mice was treated with the SSRI antidepressant citalopram. Finally, a third group was treated with vortioxetine.scans of mouse brains from each group 38 days after tumor implantation.
In a follow-up experiment, another sample of glioblastoma mice was treated with standard chemotherapy drugs. Another group was was given vortioxetine, while a third wasn'Similarly, the vortioxetine group had increased survival rates 20-30 percent above those of the chemo-only group, not just in the short term, but long-term, too.
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