Exercise-induced protein may reverse age-related cognitive decline

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Exercise-induced protein may reverse age-related cognitive decline
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A research team supported by NIHAging found that an exercise-induced protein restored age-related loss of memory and increased new brain cell growth. Their results suggest that exercise may have a rejuvenating, preventative effect on aging. Read more:

An exercise-induced protein restored age-related loss of memory and new brain cell growth in mice.The results suggest that exercise may have a rejuvenating effect in addition to a preventative effect on aging.FatCamera / E+ via Getty Images

Researchers don’t know how exercise might slow age-related cognitive decline. A better understanding of this process could point toward ways to help those who have difficulty exercising due to fragility or health conditions. The team then collected blood and plasma from both young and aged mice who were either active or sedentary. They injected their plasma into separate groups of older mice eight times over three weeks. The aged mice that received blood from the active groups showed increases in new neurons and on learning and memory tasks similar to those of the active mice themselves.

GPLD1 did not appear to enter the brain, suggesting that the protein acts through one or more molecules that interact with the brain directly. Further study will be needed to understand its mechanism of action.

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