Immunologists have uncovered new approaches to enhance protection from tumors and infections. They have revealed new insights into the metabolism of specialized cells of the immune system known as tissue-resident CD8 T cells and how they could be enhanced as immune defense weapons against tumors.
Our immune system has an ingenious trick up its sleeve. It remembers past foes, stopping potential sickness in its tracks through a phenomenon known as immunological memory. This is thanks to specialized cells -- tissue-resident memory T cells -- which reside in vital organs like the small intestine, lungs and other areas. Consider them as frontline guards, stationed exactly where trouble could strike.
"T cells destined for a life-long deployment at barrier tissue sites are professional survivalists," said Goldrath, a professor in the School of Biological Sciences' Department of Molecular Biology and senior author of the new paper."These cells are extremely good at safeguarding tissues across the body, and understanding their unique adaptation strategies teaches us how to design better immune therapeutics.
"The immune system excels at coping with pathogens and infections, but it struggles against tumors," said Reina-Campos, the study's first author. The researchers wondered if these remarkable cells hold the key to unlocking a new era of immune system innovation. This is especially relevant in the battle against stubborn tumors. Picture your immune cells adapting, thriving and evolving within their organ strongholds.
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