Mice treated aboard the International Space Station showed significantly reduced bone loss.
, finds an engineered compound given to mice aboard the International Space Station largely prevented the bone loss associated with time spent in space. The study, led by a transdisciplinary team of professors at the University of California at Los Angeles and the Forsyth Institute in Cambridge, Massachusetts, highlight a promising therapy to mitigate extreme bone loss from long-duration space travel as well as musculoskeletal degeneration on Earth.
The current mitigation strategy for bone loss relies on exercise-induced mechanical loading to promote bone formation but is far from perfect for crewmembers spending up to six months in microgravity. Exercise does not always prevent bone loss, takes up valuable crew time, and may be contraindicated for certain types of injuries.
The modified molecule was then extensively assessed by the Soo and Ting teams to determine the efficacy and safety of BP-NELL-PEG on earth. They found that BP-NELL-PEG displayed superior specificity for bone tissue without causing observable adverse effects. Both Flight and Ground mice treated with BP-NELL-PEG exhibited a significant increase in bone formation. The treated mice in space and on Earth displayed no apparent adverse health effects."Our findings hold tremendous promise for the future of space exploration, particularly for missions involving extended stays in microgravity," said lead corresponding author Chia Soo.
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