Why patients with diverticular disease are so cancer-prone might be due to several factors including the growing evidence that chronic inflammation is a potential mechanism contributing to the link between the two conditions. GITwitter
, headed by Veronika Fedirko, PhD, University of Texas MD Anderson Cancer Center, Houston."One might postulate that the lower risk could be due, at least in part, to exclusion of patients with concomitant undiagnosed diverticular disease and rectal cancer from the study and/or more effective removal of pre-cancerous lesions in the rectum...during an initial diagnosticWhy patients with diverticular disease are so cancer-prone might be due to several factors.
Lastly, there is growing evidence that chronic inflammation and gut dysbiosis in involved in the pathogenesis of diverticular disease, thus supporting chronic inflammation as a potential mechanism contributing to the link between diverticular disease and cancer. "Low overall diet quality is associated with less favorable gut microbiome profiles or dysbiotic communities that are more vulnerable to pathogens," the editorialists point out.
There is also a possible genetic link between the two diseases as in the current study, the strongest estimates for diverticular disease and cancer risk was seen in patients between 18 and 29 years of age, the editorialists also point out.
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