Bay Area scientists are infecting “organoids” with the COVID-19 virus to watch what happens.
The attack of the COVID-19 virus on the human heart is completely hidden from view, revealed only by the damage that’s left behind.
“Very rapidly, this is opening up avenues for us to look at many different organ systems,” said virologist Dr. Melanie Ott, director of theMelanie Ott, left, director of the Gladstone Institute of Virology and professor of medicine at UC San Francisco, and Mir Khalid talk in the Ott Lab at Gladstone Institutes on March 31st, 2021. Their researchIn 2006, Dr.
And they’re abundant. An estimated 10,000 different batches of iPSC-derived cells are now growing in labs all over the globe. As they differentiate and mature, these young cells want to get organized. Following the ancient choreography of human development, they clump together into three-dimensional immature mini-organs called “organoids.”
These organoids are the perfect model for studying disease. Current methods have major limitations. For instance, traditional cell cultures grow in two-dimensional layers, so don’t behave like real organs. Lab animals are useful, but they don’t always get human disease.
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