A small pilot study shows DBS to be both safe and efficacious in reducing motor impairment and improving recovery of upper limb function after stroke.
Each participant underwent DBS surgery. After discharge and recovery from the surgery, they had 3 months of rehabilitation before the device was turned on and then 4-8 months of rehabilitation combined with DBS. They continued with rehabilitation after discontinuation of stimulation treatment.The researchers evaluated changes in motor impairment and function during five key intervals.
There was a "modest" three-point median improvement across the pre-stimulation, rehab-only phase . After that, an additional seven-point improvement was observed, when rehabilitation was combined with DN-DBS . Moreover, the "robust functional gains were directly correlated with cortical reorganization evidenced by increased ipsilesional metabolism," they add.
"This emerging intervention has shown translational potential to modulate the magnitude of neuroplastic reorganization toward recovery of function and to extend its time window to late phases of disability," they conclude.
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