When it comes to predicting heart trouble down the road, do your arteries or genes say more about risk? Doctors have long used certain factors to estimate the likelihood of...
But in recent years, there have been questions about whether people's genes could provide a similar outlook. Many different gene variants have been associated withrisk, and researchers have developed so-called polygenic risk scores that, like the calcium score, correlate with the odds of developing heart trouble.
Until now, though, there had been no head-to-head comparison of the two tests' predictive potential. And, Khan said, the calcium scan emerged as the clear winner. In contrast, the polygenic risk score added no helpful information to what doctors can already glean with old-fashioned measurements. Blankstein, who was not involved in the study, pointed to a fundamental difference between the tests: CT scans detect actual signs of early artery disease, while blood tests give an idea of genetic risk.
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