Cognitive impairment is a good predictor of physical disability progression in patients with MS, new research suggests. multiplesclerosis
the likelihood of needing a wheelchair was almost doubled in those who had the worst scores on"These findings should change our world view of MS," study investigator Gavin Giovannoni, PhD, professor of neurology, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, United Kingdom, told attendees at the Congress of the European Academy of Neurology 2022.
"I urge anybody who runs an MS service to think about putting in place mechanisms in their clinic" to measure cognition of patients over time, he said.Cognitive impairment occurs very early in the course of MS and is part of the disease, although to a greater or lesser degree depending on the patient, Giovannoni noted. Such impairment has a significant impact on quality of life for patients dealing with this disease, he added..
Investigators looked at both the core study in which all patients continued on treatment or placebo for up to 37 months, and the core plus extension part in which patients received treatment for up to 5 years. In the core study, those in the worst SDMT quartile at baseline were numerically more likely to reach deterioration to EDSS 7 or greater compared with patients in the best SDMT quartile .
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