Characterizing expression changes in noncoding RNAs during aging and heterochronic parabiosis across mouse tissues
We chose the global aging miR-29c-3p as an example for further investigation. In liver and kidney, expression increased monotonically over the lifespan as well as in BAT but at a lower baseline expression . In the lung, the steep increase during early adulthood ends at approximately 12 months of age. A general trend of miR-29c-3p expression increase was present in all tissues, but expression levels and the course of increase showed tissue-specific patterns .
We assigned deregulated miRNAs to the following groups: either uniquely deregulated in rejuvenation or in accelerated aging , or deregulated in physiological aging as well as rejuvenation or accelerated aging . We found 233 uniquely deregulated miRNAs in rejuvenation and 43 in accelerated aging . Intriguingly, 17 age-related miRNAs were deregulated in the opposite direction in REJ.
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