High blood sugar in patients with type 2 diabetes, including prediabetes, was found to be causally linked to lung disorders in the first study of its kind.
Liverpool — High blood sugar in patients with type 2 diabetes, including prediabetes, was found to be causally linked to lung disorders in the first study of its kind into type 2 diabetes and lung dysfunction.
"This means that pulmonary dysfunction, such as restrictive lung disease, is a complication of type 2 diabetes," she said. "We propose that clinicians do spirometry tests for people at risk, or with diabetes, to detect lung dysfunction early and to make individuals aware of this complication. The researchers analysed data from a diverse group of nearly 500,000 participants in 17 major studies, including the UK Biobank. Controlling for factors including smoking and sedentary behaviour, the team used a statistical technique called Mendelian randomisation to understand whether high blood sugar levels were linked to impaired lung function, and whether one was causing the other. Lung function was measured using FVC and FEV1.
In terms of the biological mechanism predisposing people with type 2 diabetes to lung complications, Prof Prokopenko explained that their study did not specifically investigate the biological mechanism in this study, but said that: "Overall, vascular endothelial dysfunction is the main feature of diabetes, and this involves alteration in several biological processes, from hyperglycaemia to inflammatory activation, the latter being one of the possible explanations of the effects on...
"Lung conditions can be life-changing and life-limiting, and it is crucial that healthcare professionals are aware of the impact of high blood sugar levels on lung health. Research must now investigate how best to prevent, monitor and treat lung disorders in people with type 2 diabetes."
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