Researchers developed a polygenic risk score for CKD that performed well across ancestrally diverse populations.
Patients would provide a blood or saliva sample for DNA testing, from which a CKD risk score would be determined, he noted.The research was performed as part of the Electronic Medical Records and Genomics-IV study, a National Institutes of Health–funded nationwide study that started recruiting 20,000 participants to prospectively test risk scores for 10 common diseases.
They combined APOL1 risk genotypes with GWAS for kidney function and designed, optimized, and validated a genome-wide polygenic score for CKD. It uses robust sample sizes, he noted, with multiple representative ancestries to develop a quantitative and continuous risk score using several genetic variants across the genome.
"However, as the authors admit," he continued,"since their data did not capture the family history of kidney disease well from the medical records, whether the score will be an improvement over this knowledge in predicting CKD risk is not known from this work."
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