Women with breastcancer who have several tumors in one breast do not necessarily need to have a mastectomy, as new data show a low risk of recurrence at 5 years when they are treated with breast-conserving therapy and radiation. BCSM
Commenting on the study, Hiram S. Cody, III, MD, an attending surgeon and professor of surgery at Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center in New York City, said the findings provide valuable new evidence on the issue.
That is why the new study is so important, Cody explained."Here, we see in a prospective trial that breast-conserving therapy is feasible for those with more than one site of disease as well, with high survival and very low rates of local recurrence," he emphasized. This study showed the rate of cancer local recurrence was 3.1%, she noted. This is an excellent outcome and is similar to the local recurrence rate for patients with a single tumor in a breast who had breast-conserving therapy, Boughey said.
All patients were treated with breast conservation surgery, including lumpectomy resected to negative margins, followed by whole breast radiation with a cavity boost to all lumpectomy beds. There were no cases of synchronous local and distant recurrences, six contralateral breast cancers, and three new primary nonbreast cancers. Eight patients died, including one related to breast cancer.
Of note, among patients without a breast pre-operative MRI, the 5-year rate of local recurrence was significantly higher, at 22.6% at 5 years, compared with 1.7% among the 180 patients who did have a preoperative MRI . However, Rosenkranz said these differences should be interpreted with caution.
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