Glioblastoma (GBM) is the most common and deadliest type of brain cancer with a five-year survival rate of only 5%. Researchers at Penn State College of Medicine have identified a biomarker that can be used in blood tests to diagnose GBM, track its progression, and guide treatment. The researchers s
aid that such a non-invasive liquid biopsy for GBM could help patients get the care they need more quickly.
The team studied a certain antigen receptor, called interleukin-13 receptor α2 , which is known to be elevated in the tumor tissue of more than 75% of GBM patients. In the patients’ plasma, the researchers looked specifically at extracellular vesicles, which are small particles that are released by cells and carry material from those cells. They found that patients with GBM had significantly elevated levels of IL13Rα2 in their blood plasma compared to control patients and that the IL13Rα2 was likely concentrated on extracellular vesicles derived from tumor cells.
Interestingly, the team found that elevated levels of IL13Rα2 in both plasma and tumors predicted longer overall survival. In fact, patients with high levels of plasma IL13Rα2 had a 6.5-month longer median overall survival compared to patients with low levels.
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